Neil Rofsky, MD
Professor and Chairman
Effie and Wofford Cain Distinguished Chair in Diagnostic Imaging
Department of Radiology
UT Southwestern Medical Center
James Provenzale, MD
Department of Radiology
Division of Neuroradiology
Duke University Medical Center
Mark Beautz, RT (R) (MR)
Chief Technologist / Magnetic Resonance Imaging Center
Duke University Medical Center
Estimated amount of time to complete: 30 minutes
Since the introduction of gadolinium-based contrast agents (GBCAs) into magnetic resonance imaging (MRI) in the 1980s, multiple contrast agents have been introduced and used extensively in a wide range of indications, particularly central nervous system (CNS) examinations, evaluation of neurodegenerative disease, and assessment of tumors. Contrast enhancement provides improved tissue contrast and characterization of lesions and more sensitive detection of smaller lesions. GBCAs differ in physicochemical characteristics and function, and their stability, concentration, and relaxivity can have a significant impact on their efficacy and safety in clinical applications.
Since 2006, GBCAs have been associated with a serious medical condition called nephrogenic systemic fibrosis (NSF). Much debate has centered on the available approved contrast agents and their chemical structure and stability in relation to their use in patients with renal impairment. Guidelines and recommendations for administering contrast to these patients have evolved, and with the continued development of contrast agents and imaging techniques, the characteristics and differences between the GBCAs have become more significant in imaging decisions.
Radiologists and other health care professionals interested or involved in diagnostic imaging and its role in patient diagnosis and management.
Attention radiologic technologists: This activity is approved by ASRT for 0.5 Category A+ continuing education credit. To access this version of the activity, please click here. Learning Objectives
Upon completion of this educational activity, the participant should be able to:
Review the impact of nephrogenic systemic fibrosis on contrast MRI.
Determine when a patient with renal disease may be at risk for NSF with GBCA administration.
Discuss practical considerations for administering contrast media in patients with renal insufficiency.
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Planning committee members have no financial relationships to disclose.
The information presented in this CME program represents the views and opinions of the individual contributors, and does not constitute the opinion or endorsement of, or promotion by, Temple University School of Medicine, Temple University Health System or its affiliates. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each activity participant must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
Dr. Rofsky has no relevant financial relationships with any commercial interests to disclose.
Dr. Provenzale discloses that he receives grant/research support from GE Medical Healthcare and Bayer HealthCare Pharmaceuticals. He also serves as a consultant for Millennium and Theradex and is a stockholder in Amirsys, Inc.
Mr. Beautz has no relevant financial relationships with any commercial interests to disclose.
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There is no fee to participate and receive credit.
Attention radiologic technologists: This activity is approved by ASRT for 0.5 Category A+ continuing education credit. To access this version of the activity, please click here.
Credit Provider Contact Information
School of Medicine
The Albert J. Finestone, MD Office for CME
3500 North Broad Street Philadelphia, PA 19140
Commercial Support Statements
This educational activity is supported by an educational grant from Bayer HealthCare Pharmaceuticals.
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