Presenter Edouard Trabulsi, MD, FACS Associate Professor of Urology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA Course Chair Arthur L. Burnett, MD, MBA Patrick C. Walsh Distinguished Professor of Urology Director, Basic Science Laboratory in Neurourology Director, Sexual Medicine Fellowship Program Faculty Member, Cellular and Molecular Medicine Graduate Training Program Johns Hopkins Medical Institutions Baltimore, MD
NOTE: This activity was presented as a live visiting faculty grand rounds series beginning on April 22, 2015. Participants who received credit for attending any of the live presentations are not eligible to receive credit for this online release.
Among men in the United States, prostate cancer is the most common cancer and the second leading cause of cancer-related death. The recommended treatment options for prostate cancer vary based on disease severity and life expectancy, with traditional approaches including active surveillance, surgery, radiation therapy, and androgen deprivation therapy (ADT), also referred to as hormonal therapy. Prostate cancer that progresses despite ADT is indicated by a rise in prostate specific antigen (PSA) levels and is known as CRPC. Because most deaths from prostate cancer are due to CRPC, treatment of this form of prostate cancer is of critical importance. Recent advances in understanding the pathogenesis of CRPC have led to at least 6 new therapeutic strategies and increased optimism regarding the treatment of CRPC. This activity will address gaps in knowledge, skills, and competency of evidence-based treatment among oncology and urology clinicians.
Introduction (2 minutes)
Recent FDA approvals of new CRPC therapies (3 minutes)
Investigational therapies in late stages of development (5 minutes)
Recent updates to clinical practice guidelines (5 minutes)
Prevention of skeletal-related events in CRPC (5 minutes)
Systemic therapy for metastatic CRPC (5 minutes)
Radiopharmaceutical therapy (5 minutes)
Androgen-deprivation therapy (5 minutes)
Chemotherapy/immunotherapy (5 minutes)
Collaboration among urology and medical oncology (5 minutes)
Conclusion (5 minutes)
Produced in collaboration with MCM Education.
Urologists, medical oncologists, radiation oncologists, and other clinicians interested and involved in the treatment of patients with prostate cancer. There are no prerequisites for this activity.
After participating in this activity, the participant will demonstrate the ability to:
Summarize recent updates to clinical practice guidelines that reflect significant changes in best practices in the management of CRPC.
Describe evidence-based first- and second-line treatment regimens for CRPC.
Summarize current data for investigational therapies for CRPC in late stages of clinical development.
Discuss strategies to increase collaboration between urology and medical oncology clinicians.
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As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:
Edouard Trabulsi, MD, FACS, has no conflicts of interest to disclose.
Course Chair Arthur L. Burnett, MD, MBA, discloses the following:
Consultant: Lilly; Reflexonic, LLC; Genomic Health, Inc.; Endo Pharmaceuticals
Research Support: American Medical Systems, LLC; Coloplast; Pfizer Inc; Auxilium Pharmaceuticals, Inc.; Acorda Therapeutics, Vivus, Inc
Wm. Kevin Kelly, DO, discloses the following:
Consultant: Sanofi U.S.
Christopher Amling, MD, FACS, has no conflicts of interest to disclose.
No other planners have indicated that they have any financial interests or relationships with a commercial entity.
Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).
Off-Label Product Discussion: No off-label products discussed.
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Credit Designation Statement
The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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Commercial Support Statements
This activity is supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC., and sanofi-aventis U.S.
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