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Program Detail

Program Title

Taking the Confusion out of Chronic Hepatitis B Infection: Understanding the Natural History, Diagnosis and Treatment Options
Release Date: November-01-05
Credit Expiration Date: November-01-06


Kris V. Kowdley, MD
Professor of Medicine
University of Washington School of Medicine
Seattle, Washington

Karen Luken, MS, ARNP, FNP-C
Family Nurse Practitioner-Gastroenterology/Hepatology
Gastrointestinal Associates
Overland Park, Kansas

Richard H. Davis Jr., PA-C
Senior Physician Assistant
Department of Medicine
Division of Gastroenterology, Hepatology, and Nutrition
University of Florida
Gainesville, Florida

Family Medicine Consultant:

William A. Schwer, MD
Chairman Department of Family Medicine
Rush- Presbyterian-St. Luke’s Medical Center
Chicago, IL

Credit Hours

Physicians, PAs: 1
Nurses, NPs: 1.2


Online Presentation

Program Description

Chronic hepatitis B virus (HBV) infection is one of the most common infectious diseases worldwide, with an estimated 350 million people infected, including 1.5 million Americans. Although the availability of a vaccine against HBV has led to a reduction in the rate of infection, there is still a large reservoir of chronic HBV carriers who can transmit the disease through personal contact or to their newborn children. The ultimate prognosis for persons with chronic HBV infection is poor. These patients are at increased risk for development of decompensated liver disease, cirrhosis, and hepatocellular carcinoma, which result in approximately 6,000 deaths per year in the US.

The diagnosis of chronic HBV infection is typically made using serologic markers for HBV disease; for example, the presence of HBsAg for > 6 months indicates chronic HBV infection. Other serologic tests used to evaluate patients with chronic HBV include HBeAg, which reflects active viral replication.

There are 5 potent antiviral agents available today to treat HBV infection, and the goal of antiviral treatment is to suppress HBV replication. The challenge to the practitioner is to identify those patients with chronic HBV infection who would benefit from antiviral therapy and to select the most appropriate agent for each patient.

This program will review the epidemiology and natural history of chronic HBV infection and the current guidelines for vaccination against HBV. In addition, attention will be focused on the current serologic methods and virologic testing that are used to make the diagnosis of chronic HBV infection. Finally, the discussion will center on the treatment options available today for patients with chronic HBV infection, as well as the appropriate screening procedures used in the long-term care of these patients.

Program Developer/Facilitator


Target Audience

This educational activity is designed to meet the needs of primary care physicians, nurses, nurse practitioners, and physician assistants with an interest in the epidemiology, diagnosis, and management of chronic hepatitis B virus infection.

Learning Objectives

Upon completion of this educational activity, the participant should be able to:

  1. Review the appropriate use of hepatitis B vaccine in infants and high-risk patients.
  2. Describe the tests used to accurately make the diagnosis of chronic HBV infection, and the appropriate screening procedures for the long-term care of HBV-infected carriers.
  3. Describe the epidemiology, natural history, and risk factors for chronic hepatitis B virus (HBV) infection.
  4. Discuss how to identify candidates for treatment among patients with chronic HBV infection and the treatment options that are currently available.


AKH Inc. and its shareholders have no significant financial relationships with the manufacturers of medical or pharmaceutical products, nor with the providers of non-educational medical services. It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of their continuing education activities. The faculty must disclose to the participants any significant relationships with the commercial companies whose products or devices may be mentioned in the monograph or with the commercial supporter of this continuing education activity. The information is for participant information only; it is not assumed that these relationships will have a negative impact on the content of the activity.

Kris V. Kowdley, MD discloses that he is a member of speakers bureaus for Gilead, GlaxoSmithKline, Roche Pharmaceuticals, Bristol-Myers Squibb, and Schering-Plough, He is on advisory committees for Gilead and Bristol-Myers Squibb.

Karen Luken, MS, ARNP, FNP-C discloses that she is a member of speakers bureaus for Roche Pharmaceuticals and Schering-Plough.

Richard H. Davis Jr., PA-C discloses that he is on a speakers bureau for Schering-Plough.

William A. Schwer, MD reports that he has no significant financial interest or other relationships with the manufacturer(s) of any commercial product(s) or service(s) discussed in this educational presentation or with the commercial supporter of this activity.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents for the treatment of hepatitis B infection. Some uses of these agents may not have been approved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Credit Statements

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of AKH Inc. and Medical Communications Media. AKH Inc. is accredited by the ACCME to provide continuing medical education for physicians.

AKH Inc. designates this educational activity for a maximum of 1 category 1 credit towards the AMA Physician’s Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

This activity has been reviewed and is acceptable for up to 1 Prescribed credit(s) by the American Academy of Family Physicians. AAFP accreditation begins 11/01/05. Term of approval is for one-year(s) from this date, with option for yearly renewal.

AKH Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. AKH Inc. designates this educational activity for 1.2 contact hours.

AKH Inc. is approved as a provider of nurse practitioner continuing education by the American Academy of Nurse Practitioners. Provider #030803. AKH Inc. designates this educational activity for 1.2 contact hour(s).

This program has been reviewed and is approved for a maximum 1 hour of AAPA Category I (Preapproved) CME credit by the Physician Assistant Review Panel. Approval is valid for one year from the issue date of November 1, 2005. Participants may submit the self-assessment at any time during that period.

This program was planned in accordance with AAPA’s CME Standards for Enduring Material Programs and for Commercial Support of Enduring Material Programs.

Successful completion of the self-assessment is required to earn credit. Successful completion is defined as a cumulative score of at least 70% correct.

Commercial Support Statements

Supported by an educational grant from Bristol-Myers Squibb.


  1. Click on the "Start program" icon.
  2. The next screen will permit you to check for or download the Flash player required to run this program.
  3. Clicking on "start the program" on this screen will bring you to instructions to turn off pop-up blockers and allow you to begin the program presentation which will take approximately 60 minutes to complete.
  4. Upon completion of the program, click on the post-test button to register and access the post-test and program evaluation.
  5. Instructions for completing and submitting the post-test are provided on the post-test screen. A minimum score of 70% on the post-test is required for a CME/CE certificate.

Certificate Fee


This CME/CE activity is provided free of charge. PAs who are not members of the AAPA and wish to receive AAPA CME credit are required to pay a $20 scoring fee at the time of post-test submission.


None of the contents of this activity may be reproduced in any form without prior written permission of the publisher. The opinions expressed in this activity are those of the speakers and do not necessarily reflect the opinions or recommendations of their affiliated institutions, the publisher, AKH Inc., or Bristol-Myers Squibb. Any medications, or other diagnostic or treatment procedures discussed by the program speakers should not be utilized by clinicians without evaluation of their patients’ conditions and of possible contraindications or risks, and without a review of any applicable manufacturer’s product information and comparison with the recommendations of other authorities.

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